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Investigating the benefits and harms of blood pressure medication – Survey Study

Investigating the attitudes and beliefs of care recipients and their family members or friends towards deprescribing medication

Randomised Evaluation of Sleep Treatment to Ease Depression (RESTED)

Depression is a very common and impairing condition. Current treatments include antidepressant medication and psychological therapy. Both can be effective, but more than one-third of people do not benefit from these treatments. There are reasons to think that poor sleep is an important contributor to depression, and that if sleep could be improved, depression would improve too. Previous research has shown that we can improve sleep quality using a behavioural treatment called ‘sleep restriction therapy’. This treatment involves reviewing the patient’s current sleep pattern and supporting them to follow a new, personalised sleep schedule. We want to find out whether using this treatment to improve sleep will also improve depression and, if so, how it works.

OPTIMISE 2

PRUDENCE: Platform Randomised controlled trial of point of care Diagnostics for Enhancing the quality of aNtibiotic prescribing for Community acquired acute respiratory tract infection in ambulatory care in Europe

PRUDENCE Trial

BP:Together: Testing a new system to lower the blood pressure of people who have had Stroke or TIA or Coronary Heart Disease (Heart Attack, Heart By-pass or Stent)

PRINCIPLE: Platform Randomised trial of INterventions against COVID-19 In older peoPLE

Evaluating potential treatments for COVID-19 infection in older people.

gameChange: A randomised controlled trial testing automated virtual reality cognitive therapy for patients with fears in everyday social situations

SAFER: Screening for atrial fibrillation with ECG to reduce stroke

MICAD: Microglial CSF1R in Alzheimer’s Disease

SuMMIT-D: Support through mobile messaging and digital health technology for diabetes

EXPECT-1: Pilot Study to Assess Success Factors and Barriers for Preparation of a Phase 3 Study with ExPEC10V in Adults Aged 60 Years or Older and in Stable Health

This study is being carried out by researchers at general practices and hospitals worldwide to collect more information to support the development of a vaccine to prevent serious E-coli infections.

EXPECT-2: Prospective Epidemiological Study to Estimate the O-serotype Distribution of Extraintestinal Pathogenic Escherichia coli

Prospective Epidemiological Study to Estimate the O-serotype Distribution of Extraintestinal Pathogenic Escherichia coli (ExPEC) Isolated from Hospitalized Patients Aged 60 Years or Older with Invasive ExPEC Disease (IED) and to Evaluate the Clinical Case Definition.

PANDA-S: Prognostic AND Diagnostic Assessment of Shoulder Pain research study

This study aims to develop and test a better approach to assessing the likely cause (diagnosis) and future outcome (prognosis) of shoulder problems (pain).

Optimise HFpHF: Optimising Management of Patients with Heart Failure with Preserved Ejection Fraction in Primary Care

ALABAMA: ALlergy AntiBiotics And Microbial resistAnce

Penicillin allergy status and its effect on antimicrobial prescribing, patient outcomes, and antimicrobial resistance.

Value-Dx: Point Prevalence Audit Survey

Community acquired acute respiratory tract infection (CA-ARTI) in community care in Europe: point prevalence audit study (PPAS) of presentation and management.

FOUND: Case Finding of Obstructive sleep apnoea in primary care Using a Novel Device

NewKI: New onset Kidney Impairment Study

HABIT: Health professional Administered Brief Insomnia Therapy Trial

A pragmatic, multicentre, randomised controlled trial comparing nurse delivered sleep restriction therapy for insomnia disorder to sleep hygiene in primary care.