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New research project aims to develop a patient and public involvement (PPI) intervention to enhance recruitment and retention in surgical trials.

latest news

We recently carried out 6 focus groups with surgical trial staff and PPI contributors from across the UK. Thank you to everyone who took part! We are currently analysing the information and look forward to sharing the findings. Stage 3 of 4 (online survey) will kick off in Spring next year.

Background

Clinical trials, including surgical trials, often struggle to recruit patient participants and keep them in the trial (retention). These difficulties can mean a trial takes longer, costs more money, or even fails completely.

Patient and public involvement (PPI) is research being carried out ‘with’ or ‘by’ patients and/or members of the public rather than ‘to’, ‘about’ or ‘for’ them. PPI in designing and doing trials has the potential to enhance recruitment and retention, but the evidence for this is weak at best. We also don’t know what kind of PPI is likely to lead to the biggest improvements in recruitment and retention.

Aims

We are going to investigate these issues by developing and testing a PPI ‘intervention’ aimed at improving recruitment and/or retention in surgical trials. We plan to develop an intervention that is as practical and useful as possible by involving surgical trial investigators, administrators, PPI coordinators and PPI contributors (patients and members of the public involved in surgical trials) in the development process. We will be inviting people in these roles across the UK to take part from September 2015. The project will consist of several phases including surveys, focus groups and a consensus workshop.

We hope that this exciting project will improve our understanding of PPI impact and of recruitment and retention challenges in surgical trials, as well as providing an evidence-based PPI intervention which could be realistically used in practice.

Click here to view study materials.

Click here to view a webinar about the project given on 24th September 2015 (part of the MRC Network of Hubs for Trials Methodology Research – Trial Conduct Working Group webinar series).

project team

 

Joanna Crocker

Health Experiences Institute, University of Oxford and NIHR Oxford Biomedical Research Centre

Richard Bulbulia

Clinical Trial Service Unit, Nuffield Department of Population Health and MRC CTSU Hub for Trials Methodology Research, University of Oxford

Jennifer Bostock

Lay Partner

Alan Chant

Patient Partner

Jonathan Cook

Surgical Intervention Trials Unit, University of Oxford, and MRC ConDuCT-II Hub for Trials Methodology Research

Nicola Farrar

Surgical Intervention Trials Unit, University of Oxford

Jenny Hislop

Health Experiences Research Group, University of Oxford

Louise Locock

Health Experiences Research Group, University of Oxford, and NIHR Oxford Biomedical Research Centre

Sophie Petit-Zeman

NIHR Oxford Biomedical Research Centre and Unit

Keira Pratt-Boyden

Health Experiences Research Group, University of Oxford

Sian Rees

Health Experiences Institute, University of Oxford

Shaun Treweek

Health Services Research Unit, University of Aberdeen

Kerry Woolfall

Institute of Psychology, Health and Society, University of Liverpool and MRC North West Hub for Trials Methodology Research


Collaborators and Advisors

Jane Blazeby, MRC ConDuCT-II Hub for Trials Methodology Research, University of Bristol

Louise Bowman, MRC CTSU Hub for Trials Methodology Research, Clinical Trial Service Unit, University of Oxford

Cushla Cooper, Surgical Intervention Trials Unit, University of Oxford

Loretta Davies, Surgical Intervention Trials Unit, University of Oxford

Simon Denegri, National Institute for Health Research and INVOLVE

David Evans, University of the West of England

Nader Francis, Yeovil District Hospital NHS Foundation Trust

Alison Halliday, Nuffield Department of Surgical Sciences, University of Oxford

Allison Hirst, IDEAL Collaboration

Adwoa Hughes-Morley, Institute of Population Health, University of Manchester

Emma Jones, Department of Health Sciences, University of Leicester

Simon Knight, Centre for Evidence in Transplantation and Nuffield Department of Surgical Sciences, University of Oxford

Laura Magill, Birmingham Surgical Trials Consortium

Patients Active In Research, NIHR Oxford Biomedical Research Centre

Peter McCulloch, IDEAL Collaboration and University of Oxford

Michael Osborne, Patient Contributor

David Simpson, Lay Contributor

Rosamund Snow, Patient Advisor and University of Oxford

Tim Sprosen, Clinical Trial Service Unit, University of Oxford

 


More information

For more information please contact the lead researchers:

Joanna Crocker (joanna.crocker@phc.ox.ac.uk), Postdoctoral Research Fellow, Health Experiences Institute, University of Oxford and NIHR Oxford Biomedical Research Centre or

Richard Bulbulia (richard.bulbulia@ctsu.ox.ac.uk), Consultant Vascular Surgeon, Clinical Trial Service Unit, Nuffield Department of Population Health, University of Oxford.

The study is supported by the NIHR Oxford Biomedical Research Centre and the MRC Network of Hubs for Trials Methodology Research, and is part of the Trial Forge initiative to improve trial efficiency.