Past trials

The studies conducted in our Clinical Trials Unit have been instrumental in shaping primary care practices and improving patient outcomes. Completed studies have advanced medical knowledge, evaluated new treatments, and informed evidence-based guidelines.

Our archive of completed trials shares each study's objectives, methodologies, and key findings, demonstrating the breadth and depth of our research expertise. Discover how our clinical trials have made lasting impacts on medical practices and patient care.

	Trial	condition	Status
	ALABAMA – A trial to find out if people with a penicillin-allergy label in their GP health records really do have an allergy by specialist testing, and to see if we can reduce the number of patients wrongly labelled as penicillin allergic	Penicillin allergy	Completed
	BARACK-D – A multi-centre trial to investigate the use of spironolactone in treating chronic kidney disease	Chronic kidney disease	Completed
	BUMP – A study to explore whether giving pregnant women the means to monitor their own blood pressure and urine safely from home can result in an earlier diagnosis of raised blood pressure (hypertension) and pre-eclampsia, resulting in faster access to treatment	Raised blood pressure (hypertension)	Completed
	CUTI – A feasibility study that aimed to find out whether cranberries actually treat UTIs and help reduce the need for antibiotics	Urinary tract infections	Completed
	gameChange – A study to investigate a virtual reality treatment for people with psychosis	Psychosis	Completed
	HABIT – A study to investigate two methods of treating insomnia	Insomnia	Completed
	MERIT – A trial that investigated the use of a food supplement in the treatment of chronic UTIs	Urinary tract infections	Completed
	OPTiMISE – A study that assessed the safely of reducing the amount of blood pressure medication taken by older people using self-monitoring of blood pressure	Raised blood pressure (hypertension)	Completed
	PANORAMIC – A UK-wide clinical study to investigate if new antiviral treatments for COVID-19 in the community reduced the need for hospital admission	COVID-19	Completed
	PETRUSHKA – A trial that aimed to personalise pharmacological treatment for adults with major depressive disorder in the NHS	Major depressive disorder	Completed
PRINCESS	PRINCESS – A trial to investigate whether a probiotic supplement could reduce the number of bacterial infections in care home residents	Bacterial infections	Completed
	PRINCIPLE – A study that aimed to find medicines that could help people with COVID-19 symptoms to recover quickly at home rather than requiring admission to hospital	COVID-19	Completed
	PRUDENCE – A study to investigate using a diagnostic test before prescribing antibiotics for acute respiratory tract infections	Acute respiratory tract infections	Completed
	SYMPLIFY – A study to evaluate a blood test to detect over 50 types of cancer	Cancer	Completed

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Past trials

Trial

condition

Status

PRINCESS