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« Back to NewsAntiviral molnupiravir offers only modest longer-term benefits for COVID-19, finds new paper from the PANORAMIC trial
10 September 2024
Can the long-term consequences of COVID 19 be reduced through the use of novel antiviral medicines? New research from the PANORAMIC trial, run in NDPCHS Clinical Trial Unit and funded and delivered by the NIHR, has found that treating vaccinated, higher-risk adults with COVID-19 with the antiviral drug molnupiravir offers only modest benefits when it comes to reducing long term effects of the acute illness.
The scale of Long COVID: New study highlights the widespread impact
1 August 2024
A comprehensive state-of-the-art review published today in The Lancet has revealed the widespread impact of Long COVID, providing crucial insights into the condition's biological mechanisms and outlining key areas for future research.
Study shows disparity in COVID-19 vaccines uptake for immunocompromised individuals, despite evidence of vaccine effectiveness and safety
13 June 2024
A new study by researchers at NDPCHS has shown disparities in vaccine uptake in immunocompromised individuals across ethnic and socioeconomic groups, despite evidence that vaccines are safe and effective for patients with weakened immune systems.
PRINCIPLE and PANORAMIC teams honoured with prestigious Prix Galien Award
3 June 2024
Awards & appointments COVID-19 Clinical trials
The teams behind the PRINCIPLE and PANORAMIC clinical trials, run in the Clinical Trials Unit at the Nuffield Department of Primary Care Health Sciences, have been awarded the prestigious Prix Galien Best Public Sector Innovation Award 2024 for their work in conducting innovative, large-scale clinical trials during the COVID-19 pandemic.
Comprehensive review confirms mask effectiveness against respiratory infections, urges better design and policy support
22 May 2024
COVID-19 Infection, Respiratory and Acute Care Policy & health systems
New comprehensive review provides strong evidence that masks and respirators effectively reduce the transmission of respiratory infections like COVID-19, based on analysis of over 400 studies from multiple disciplines.
Celebrating collaboration and resilience: The PRINCIPLE PANORAMIC art exhibition
21 March 2024
Celebrate the resilience and collaboration behind Oxford's groundbreaking PANORAMIC and PRINCIPLE COVID-19 trials through "The PANORAMIC PRINCIPLE" exhibition. Artist Tanya Poole's powerful portraits honour the diverse array of participants, researchers, and medical professionals whose inclusive efforts set global benchmarks and transformed lives. An inspiring tribute to human determination in the face of adversity.
New study shows ivermectin lacks meaningful benefits in COVID-19 treatment
13 March 2024
New research led by the University of Oxford has concluded that the antiparasitic drug ivermectin does not provide clinically meaningful benefits for treating COVID-19 in a largely vaccinated population.
New study suggests antiviral treatment course is not long enough to treat COVID-19 in at risk patients
26 February 2024
New research published in Nature Communications suggests that the currently recommended five-day course of molnupiravir, an antiviral treatment, may not be long enough to treat COVID-19.
PANORAMIC trial finds molnupiravir may not be a cost-effective treatment for COVID-19 in at-risk adults
28 January 2024
A new evaluation from the University of Oxford’s ongoing PANORAMIC trial suggests that an antiviral treatment, called molnupiravir, used to treat COVID-19 may not be cost-effective at its current price of £513 per course, compared to usual NHS care and support, in the first six months after infection. However, it may be beneficial for patients over the age of 75.
Study shows detrimental impact of Long Covid on the education and lives of children and young people
20 September 2023
COVID-19 Health experiences Patient experience
New research from the Nuffield Department of Primary Care Health Sciences, University of Oxford, and the universities of Stirling and Aberdeen, funded by the National Institute for Health and Care Research (NIHR), highlights the profound effect Long Covid can have on children and young people’s school experience and wider lives.
Inequalities in COVID-19 vaccine uptake remain among people with blood cancers
15 February 2023
COVID-19 Cancer Infection, Respiratory and Acute Care QResearch
People with blood cancers are among the most clinically vulnerable individuals to COVID-19 in the UK, and a new analysis of over 12 million patient health records has revealed inequalities in COVID-19 vaccine uptake among this group.
Clinician-patient communication about emergency aerial medical evacuation in case of infectious disease
1 February 2023
COVID-19 Global perspective Patient experience Policy & health systems
New research from the University of Oxford, published today in the Journal of Travel Medicine, has developed a simple six-step check list clinicians can use to improve communication, decision making and planning about the possibility and practicalities of Aerial Medical Evacuation (AME).
Professor Chris Butler addresses the UN on PANORAMIC - BAPS UK & Europe collaboration
24 January 2023
COVID-19 Clinical trials Public engagement & involvement
Recently, Professor Chris Butler addressed the United Nations regarding the PANORAMIC Trial and the assistance of BAPS UK & Europe.
PANORAMIC trial finds molnupiravir does not reduce COVID-19 hospitalisation/deaths in vaccinated people at high risk
22 December 2022
Researchers from the University of Oxford have today released findings from a clinical trial investigating the effectiveness of the antiviral treatment molnupiravir against COVID-19 – the first treatment tested in the ongoing PANORAMIC trial.
Study reveals association between diagnosis of a neuropsychiatric condition and severe outcome from COVID-19 infection, and other severe acute respiratory infections
14 November 2022
COVID-19 Digital health & innovation Policy & health systems
New research from the University of Oxford has shown an increased risk of severe illness and death from both COVID-19 and other severe respiratory infections, such as influenza and pneumonia, among people with a pre-existing mental health condition.
World Diabetes Day, 14 November 2022: 'Education to protect tomorrow'
14 November 2022
COVID-19 Research methods & EBM
World Diabetes Day gives us an opportunity to reflect on, and recognise, all the great research being done across the Nuffield Department of Primary Care Health Sciences and Centre for Evidence-Based Medicine (CEBM), to review the evidence on COVID-19 and diabetes.
COVID-19 vaccine protects people of all body weights from hospitalisation and death, a study of 9 million adults in England finds
1 July 2022
COVID-19 Health behaviours QResearch
Two doses of the COVID-19 vaccine are effective against severe disease for people who are underweight, overweight, or who have obesity, finds new research published in The Lancet Diabetes and Endocrinology, led by researchers at the University of Oxford.
The PRINCIPLE Trial - two years on
16 May 2022
The PRINCIPLE Trial has led the way in evaluating treatments for COVID-19 in the community over the last two years.
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