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BP:Together: Testing a new system to lower the blood pressure of people who have had Stroke or TIA or Coronary Heart Disease (Heart Attack, Heart By-pass or Stent)

PRINCIPLE: Platform Randomised trial of INterventions against COVID-19 In older peoPLE

Evaluating potential treatments for COVID-19 infection in older people.

gameChange: A randomised controlled trial testing automated virtual reality cognitive therapy for patients with fears in everyday social situations

COMET: Near-patient testing to guide COPD maintenance treatment in primary care

PC SHOP: An intervention study to improve food shopping and prevent cardiovascular disease among patients in primary care

SAFER: Screening for atrial fibrillation with ECG to reduce stroke

DROPLET (Extended follow up): Doctor Referral of Overweight People to Low Energy total diet replacement Treatment

Hospital at Home: Comprehensive geriatric assessment in a HAH setting

MICAD: Microglial CSF1R in Alzheimer’s Disease

SuMMIT-D: Support through mobile messaging and digital health technology for diabetes

ARCHIE: The early use of Antibiotics in at Risk CHildren with InfluEnza

ARCHIE is a double-blind randomised placebo-controlled trial conducted in primary and secondary care settings which aims to determine whether giving the antibiotic co-amoxiclav to ‘at risk’ children within 5 days of them becoming ill with flu or influenza-like illness might: 1. Help stop them from developing bacterial infections and becoming more unwell. 2. Help them get better more quickly. 3. Affect how well antibiotics work against similar infections in future.

CONDUCT: The effectiveness and acceptability of two urine collection devices that aim to reduce contaminated urine samples in women presenting with symptoms of urinary tract infection

This trial will compare how many of the urine samples have been contaminated in each of the three groups using different methods. This study will also find out if the devices are cost-effective and how acceptable they are to patients and GPs.

EXPECT-1: Pilot Study to Assess Success Factors and Barriers for Preparation of a Phase 3 Study with ExPEC10V in Adults Aged 60 Years or Older and in Stable Health

This study is being carried out by researchers at general practices and hospitals worldwide to collect more information to support the development of a vaccine to prevent serious E-coli infections.

EXPECT-2: Prospective Epidemiological Study to Estimate the O-serotype Distribution of Extraintestinal Pathogenic Escherichia coli

Prospective Epidemiological Study to Estimate the O-serotype Distribution of Extraintestinal Pathogenic Escherichia coli (ExPEC) Isolated from Hospitalized Patients Aged 60 Years or Older with Invasive ExPEC Disease (IED) and to Evaluate the Clinical Case Definition.

PANDA-S: Prognostic AND Diagnostic Assessment of Shoulder Pain research study

This study aims to develop and test a better approach to assessing the likely cause (diagnosis) and future outcome (prognosis) of shoulder problems (pain).

OPTIMISEHFpEF: Optimising Management of Patients with Heart Failure with Preserved Ejection Fraction in Primary Care

TARS: Trial of physical activity assisted reduction of smoking

STREAM: Screen and TREAt for Malnutrition

ALABAMA: ALlergy AntiBiotics And Microbial resistAnce

Penicillin allergy status and its effect on antimicrobial prescribing, patient outcomes, and antimicrobial resistance.

Value-Dx: Point Prevalence Audit Survey

Community acquired acute respiratory tract infection (CA-ARTI) in community care in Europe: point prevalence audit study (PPAS) of presentation and management.